Interaction of Radiation with Matter: specific ionization, linear energy transfer(LET). Mechanisms and energy transfer of Heavy charged particles (Bethe-Bloch formula, Bragg curve, energy requirements, etc), fast electrons, gama rays, neutron physics including attenuation and moderation. Nuclear reactions: general features of nuclear reactions, elastic scattering, direct reaction, compound nucleus reaction. Heavy ions reaction. Brief review of concepts and principles of reactors and criticality